79412-76-3

Upstream product

• 3731-38-2 3-Quinuclidinone 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 

Downstream Products

• 79412-63-8 3-(3-hydroxyphenyl)quinuclidin-2-ene hydrobromide 
• 79412-64-9 3-(3-hydroxyphenyl)quinuclidine hydrobromide 

Relevant academic research and scientific papers

THERAPEUTIC USE OF SUBSTITUTED BENZENES, FORMULATIONS THEREOF AND NOVEL SUBSTITUTED BENZENES

Benzenes, substituted by a non-aromatic, non-fused 1-azabicycle and a substituent of low lipophilicity or a hydrocarbon substituent, their salts and prodrugs are useful in medicine, for example, in treating dementia. Some formulations of such benzenes are

3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.