79442-81-2Relevant academic research and scientific papers
An efficient one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides
Su, Wei-Nien,Lin, Tsung-Ping,Cheng, Kaung-Min,Sung, Kuan-Chin,Lin, Shao-Kai,Wong, Fung Fuh
experimental part, p. 831 - 837 (2010/08/20)
(Chemical Equation Presented) A "one-pot" method for the synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N-(1,3-diph
PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 31, (2008/06/13)
The present invention is directed to compounds which are allosteric modulators of metabotropic glutamate receptors, including the mGluR5 receptor, and which are useful in the treatment of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
Studies on the Synthesis of Heterocyclic Compounds. Part VI. The Action of Methyl Salicylate on Some 5-Aminopyrazoles
Daidone, Giuseppe,Plescia, Salvatore
, p. 747 - 750 (2007/10/02)
Some 1-phenyl-3-R-5-aminopyrazoles reacted with methyl salicylate to give N-(1-phenyl-3-R-pyrazol-5-yl)-2-methoxybenzamides (3a,b,c), 1-phenyl-2-methyl-3-R-salicyloilimino-3-pyrazolines (4a,b,c) together with 1-phenyl-3-R-5-methylamino pyrazoles (5a,b,c).The structures of the new compounds 3 and 4 were determined on the basis of analytical and spectroscopic data as well as on the acid hydrolysis products.
