794491-99-9Relevant academic research and scientific papers
Catalytic asymmetric syntheses of α-amino and α-hydroxyl acid derivatives
Han, Xiaojun,Jiang, Xiang-Jun,Civiello, Rita L.,Degnan, Andrew P.,Chaturvedula, Prasad V.,Macor, John E.,Dubowchik, Gene M.
experimental part, p. 3993 - 3996 (2009/10/01)
(Chemical Equation Presented) Herein we report the first room temperature Heck reaction of aryl bromides and CH2=C(NHP)CO2Me (P = Boc or CBz) to form ArCH=C(NHP)CO2Me, which are then used for the asymmetric syntheses of α-
Calcitonin gene related peptide receptor antagonists
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, (2008/06/13)
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
