794552-13-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors
Gryshchenko, Andrii Anatoliyovych,Levchenko, Kostiantyn Vasyliovych,Bdzhola, Volodymyr Grygorovich,Ruban, Tatiana Panasivna,Lukash, Lyubov Leonidovna,Yarmoluk, Sergiy Mikolayovych
, p. 126 - 132 (2015/03/03)
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1- sulfonamide inhibited FGFR1 with IC50 of 2 μM. In our preliminary studies, N-phenylnaphthos-tyril- 1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents.
