79456-90-9

Upstream product

• 696-23-1 2-methyl-4-nitro-1H-imidazole 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 79457-06-0 3-(4-Chloro-phenyl)-6-methyl-8-nitro-1-(4-nitro-phenyl)-1,4-dihydro-imidazo[5,1-c][1,2,4]triazine 
• 57338-61-1 3-(4-chloro-phenyl)-6-methyl-8-nitro-1,4-dihydro-imidazo[5,1-c][1,2,4]triazine 
• 57338-59-7 5-bromo-1-(4'-chlorophenacyl)-2-methyl-4-nitroimidazole 

Relevant academic research and scientific papers

Azoles. 34. Nitroimidazole derivatives and their antibacterial and fungicidal action

Nitroimidazole derivatives 4a-4c, 5a-5c, 8a-8c and 9a-9c were synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazole (1,2) or their silver salts [1.Ag,, 2.Ag) with chlorosubtituted phenacyl bromides 3a-3c, diethyl sulphate or ethyl iodide, allyl iodide and ethyl chloro-, azo- or bromoacetate. 2,4(5)-dinitroimidazole (10) has been converted to the 2,4-dinitroimidazole derivative 10a by the action of ethyl bromoacetate in the presence of sodium ethylate. A modified method for the synthesis of 6a and 6b has been described. 7a and 7b have been obtained by a known method. Some of the newly synthesized nitroimidazole derivatives show antibacterial and fungicidal activity.

CONDENSED IMIDAZO-1,2,4-AZINES. 4. SYNTHESIS OF 1,4-DIHYDROIMIDAZO-1,2,4-TRIAZINE DERIVATIVES

The reaction of 2-methyl-4(5)-nitro- and 2-methyl-4(5)-nitro-5(4)-bromoimidazoles with α-haloketones was investigated, during which a number of 1-acylmethyl-substituted 2-methyl-4-nitro- and 2-methyl-4-nitro-5-bromoimidazoles were obtained. 1,4-Dihydro de