79457-63-9Relevant academic research and scientific papers
Remote Amino Acid Recognition Enables Effective Hydrogen Peroxide Activation at a Manganese Oxidation Catalyst
Costas, Miquel,Olivo, Giorgio,Vicens, Laia
supporting information, (2021/12/27)
Precise delivery of a proton plays a key role in O2 activation at iron oxygenases, enabling the crucial O?O cleavage step that generates the oxidizing high-valent metal–oxo species. Such a proton is delivered by acidic residues that may either
Transformations of 1-(oxiranylmethyl)-1,2,3-triazoles into 2-(Oxiranylmethyl)-1,2,3-triazoles and alkanenitriles
Osawa, Ayumi,Mera, Akane,Namba, Kosuke,Tanino, Keiji
, p. 207 - 210 (2013/02/25)
New reactions for the transformation of 1-(oxiranylmethyl)-1,2,3-triazoles into 2-(oxiranylmethyl)-1,2,3-triazoles or alkanenitriles were established. Successive treatment of the substrate with triflic acid and t-BuOH afforded 4,6-dihydro-5-hydroxy-1,3a,6a-triazapentalene derivative. Under the influence of NaH, the bicyclic compound was converted into a 2-(oxiranylmethyl)-1,2,3- triazole or an alkanenitrile. The reaction pathway depends on the substituent pattern of the epoxide side chain. Georg Thieme Verlag Stuttgart New York.
Reaction of (α-halogenoalkyl)thiiranes with nucleophilic reagents I. Reaction with morpholine
Tomashevskii, A. A.,Sokolov, V. V.,Potekhin, A. A.
, p. 1610 - 1618 (2007/10/03)
By means of deuterated compounds it was established that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial opening of the thiirane ring followed by recyclization.In the case of (bromomethyl)thiirane direct substitution of the bromine begins to compete with this mechanism. 2-Methyl-2-(chloromethyl)thiirane, 2,2-dimethyl-3-(chloromethyl)thiirane, and the diastereomeric (1-chloroethyl)thiiranes were synthesized, and their reactivity toward morpholine was studied.
REACTIONS OF α,α-DIMETHYLALLYL ALCOHOL WITH POSITIVE CHLORINATION REAGENTS: SYNTHESIS OF 1-CHLORO-2,3-EPOXY-3-METHYLBUTANE
Bentley, Stuart,Goosen, Andre,Laue, Hugh A. H.,Taljaard, Benjamin
, p. 1566 - 1590 (2007/10/02)
Various approaches to the synthesis of the title compound, 1-chloro-2,3-epoxy-3-methylbutane, via the chlorination reactions of α,α-dimethylallyl alcohol have been followed.Attempted one-step synthesis of the epoxide from the substrate alcohol with either highly alkaline sodium hypochlorite, or t-butyl hypochlorite in the absence of solvent, gave mediocre yields of epoxide, accompanied by a variety of chlorinated products via mechanistic pathways proposed to involve neighbouring group participation (NGP) of the hydroxyl moiety.Good overall yields of epoxide were obtained in a two step synthesis involving chlorination of the alcohol with chlorine gas in solvent, followed by treatment of the chlorohydrin product with either base or dry silica gel.
