79473-06-6

Usage

Molecular Structure

Consists of a nitro-substituted indole ring attached to an acetic acid moiety.

Functional Groups

Has a nitro group at the 6th position of the indole ring and a carboxylic acid group attached to the 2nd position of the indole ring.

Heterocyclic Aromatic Compound

Derived from indole, which is a heterocyclic aromatic organic compound commonly found in nature.

Useful in Chemical Reactions

The presence of both functional groups makes it useful in various chemical reactions.

Biological Activities

May exhibit interesting biological activities due to its structural features.

Research Interest

Of interest to researchers in the fields of organic synthesis, medicinal chemistry, and biochemistry.

Upstream product

• 7255-88-1 (6-nitro-1H-indol-3-yl)acetonitrile 
• 4769-96-4 6-nitroindole 
• 22979-90-4 trimethyl-(6-nitro-indol-3-ylmethyl)-ammonium; iodide 

Downstream Products

• 79473-08-8 (6-amino-indol-3-yl)-acetic acid 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

A substituted indole -3 - acetic acid synthesis method (by machine translation)

The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)