79474-33-2Relevant academic research and scientific papers
Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety
Feng, Lianshun,Lv, Kai,Liu, Mingliang,Wang, Shuo,Zhao, Jing,You, Xuefu,Li, Sujie,Cao, Jue,Guo, Huiyuan
, p. 125 - 136 (2012/11/07)
A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: 90: 1 μg/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 μg/mL). Crown Copyright
NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS
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Page/Page column 320, (2008/06/13)
Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.
Highly enantioselective synthesis of no-carrier-added 6-[ 18F]fluoro-L-dopa by chiral phase-transfer alkylation
Lemaire, Christian,Gillet, Steve,Guillouet, Stephane,Plenevaux, Alain,Aerts, Joel,Luxen, Andre
, p. 2899 - 2904 (2007/10/03)
[18F]Fluoro-L-dopa, an important radiopharmaceutical for positron emission tomography (PET), has been synthesized using a phase-transfer alkylation reaction. A chiral quaternary ammonium salt derived from a Cinchona alkaloid served as phase-tra
