79479-35-9

Basic information

• Product Name: H-Arg(Mts)-Gly-OMe
• Synonyms: H-Arg(Mts)-Gly-OMe
• CAS NO: 79479-35-9
• Molecular Weight: 427.525
• Mol File: 79479-35-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: H-Arg(Mts)-Gly-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: H-Arg(Mts)-Gly-OMe(79479-35-9)
• EPA Substance Registry System: H-Arg(Mts)-Gly-OMe(79479-35-9)

Safety Data

• Hazardous Substances Data: 79479-35-9(Hazardous Substances Data)

Upstream product

• 139087-63-1 Boc-Arg(Mts)-Gly-OMe 
• 79479-34-8 Z(OMe)-Arg(Mts)-Gly-OMe 

Downstream Products

• 108304-80-9 Z(OMe)-Tyr-Pro-Arg(Mts)-Gly-OMe 
• 100007-45-2 Z(OMe)-Tyr-Pro-Arg(Mts)-Gly-NHNH₂ 
• 388077-13-2 Boc-Asp(OBn)-D-Phe-ψ[(E)-CH=CH]-Val-Arg(Mts)-Gly-OH 
• 461696-71-9 cyclo[-Asp(OBn)-D-Phe-ψ[(E)-CH=CH]-Val-Arg(Mts)-Gly-] 
• 388077-12-1 Boc-D-Phe-ψ[(E)-CH=CH]-Val-Arg(Mts)-Gly-OH 
• 388077-11-0 Boc-D-Phe-ψ[(E)-CH=CH]-Val-Arg(Mts)-Gly-OMe 

Relevant articles and documents

Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics.

Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres corresponding to dipeptides having one N-methylamino acid, and application to bioactive peptides, are described. In a key reaction introducing the chiral alpha-alkyl group of the isosteres, organocopper-mediated alkylation of syn-beta-methylated gamma-mesyloxy-alpha,beta-enoate 26a afforded E- and Z-isomers of anti-S(N)2' products in a solvent-dependent manner. The resulting two isosteres, D-Phe-psi[(E)-CH=CMe]-L-Val 27a and D-Phe-psi[(Z)-CH=CMe]-L-Val 28b, which corresponded to trans- and cis-conformers of D-Phe-L-MeVal, respectively, were utilized in a structure-activity relationship study on cyclic RGD peptides 1 and 2, in company with a psi[(E)-CH=CH]-type alkene dipeptide isostere, D-Phe-psi[(E)-CH=CH]-L-Val. The cyclic isostere-containing pseudopeptides 3, 4, and 40 were synthesized and biological activity against integrin alpha(V)beta(3) and alpha(IIb)beta(3) receptors were also evaluated.