79494-95-4Relevant academic research and scientific papers
Original synthesis of linear, branched and cyclic oligoglycerol standards
Cassel, Stephanie,Debaig, Catherine,Benvegnu, Thierry,Chaimbault, Patrick,Lafosse, Michel,Plusquellec, Daniel,Rollin, Patrick
, p. 875 - 896 (2007/10/03)
A variety of authentic standards of linear, branched and cyclic oligomers of glycerol, with well-defined structures and degrees of polymerisation from 2 to 5, have been efficiently synthesised. Linear oligomers were obtained by means of a convergent approach based on regioselective opening of bis(epoxides) with solketal; branched compounds were synthesised using oxidative cleavage of the corresponding anhydrohexitols as the key step. A 6-exo-trig halocyclisation reaction involving heteroatom-tethered unsaturated alcohols permitted an efficient synthesis of the precursors of selected cyclic dimers; larger cyclic oligomers were prepared by two one-pot Williamson reactions using a ditriflate derived from diglycerol. All these methodologies permitted further scaling up.
The reaction between epichlorohydrin and polysaccharides: Part 2, synthesis of some model substances, with cyclic substituents
Holmberg, Lars,Lindberg, Bengt,Lindqvist, Bengt
, p. 47 - 56 (2007/10/02)
Eight derivatives of methyl α-D-glucopyranoside, in which the substituents are part of cyclic structures, have been prepared as model substances for possible structural elements formed on reaction of polysaccharides with epichlorohydrin.The substances were converted into the permethylated alditol-1-d acetates and characterised by CIMS and EIMS. Keywords: Cross-linked polysaccharides; Epichlorohydrin
Anti-arrhythmia agents
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, (2008/06/13)
Acetamide derivatives are provided having the structure STR1 wherein X is a single bond, --CH2 -- or --O--, R1 and R2 may be the same or different and are lower alkyl, phenyl-lower alkoxy-lower alkyl, lower alkenyl, phenyl-lower alkyl or lower alkoxy, or STR2 may be taken together to form a 5- to 7-membered heterocyclic ring optionally containing one other hetero atom, such as nitrogen, sulfur or oxygen; Y is hydroxyl, OR wherein R is lower alkyl, lower alkenyl or lower alkanoyl, or STR3 wherein R1 and R2, and R1 and R2 taken together with the nitrogen to which they are attached are as defined above, and n is 1 to 6. These compounds are useful as anti-arrhythmia agents and have been found to be effective in the treatment of acute myocardial infarction.
