79512-50-8

Basic information

• Product Name: PHTHIOBUZONE
• Synonyms: PHTHIOBUZONE;phtiobuzone
• CAS NO: 79512-50-8
• Molecular Formula: C14H15N7O2S2
• Molecular Weight: 377.4446
• Mol File: 79512-50-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHTHIOBUZONE(CAS DataBase Reference)
• NIST Chemistry Reference: PHTHIOBUZONE(79512-50-8)
• EPA Substance Registry System: PHTHIOBUZONE(79512-50-8)

Safety Data

• Hazardous Substances Data: 79512-50-8(Hazardous Substances Data)

Usage

General Description

Phthiobuzone, also known as 2-ethylsulfinyl-6-methyl-4-phenylpyrimidine, is a medication that belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It was first synthesized and investigated for its potential anti-inflammatory and analgesic properties in the 1960s, but has since been largely discontinued in most countries due to its potential toxic effects on the liver. Phthiobuzone was primarily used as a pain reliever and anti-inflammatory medication, and was also sometimes prescribed for the treatment of fever. However, its use has declined due to the availability of safer and more effective NSAIDs with fewer adverse effects. Despite its declining use, phthiobuzone remains of interest in the scientific community due to its unique chemical structure and potential for further study in the field of drug discovery and development.

Upstream product

• 21860-84-4 2-phthalimidopropionic acid 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1074-82-4 potassium phtalimide 
• 79-19-6 thiosemicarbazide 

Relevant articles and documents

Preparation method of ftibamzone

The invention discloses a preparation method of ftibamzone. The preparation method comprises the following steps: firstly, preparing 3-phthalimide butanone from phthalimide potassium salt and 3-chlorobutanone; reacting the 3-phthalimide butanone with dry hydrogen bromide gas in a dimethyl sulfoxide solution to prepare a dimethyl sulfoxide solution of 3-phthalimide-2-oxy-n-butyraldehyde; dropwise adding a thiosemicarbazide solution into the dimethyl sulfoxide solution of the 3-phthalimide-2-oxy-n-butyraldehyde, controlling the reaction temperature, carrying out heat preservation reaction to prepare a crude product, and recrystallizing the crude product to obtain the ftibamzone. The technical scheme has the advantages of few reaction steps, high yield and high purity.

Method for synthesizing 3 - phthalatic imide - 2 - oxo-butyl - 1, 2 - double-thiosemicarbazone method

The invention relates to a novel method of synthesizing 3-phthalimide-2-oxobutryaldehyde-1, 2-bis-thiosemicarbazide. The novel method comprises the following steps: synthesizing 3-nitro-2-butanol with acetaldehyde and nitroethane as starting raw materials, then carrying out reduction on 3-nitro-2-butanol to generate 3-amino-2-butanol, carrying out reaction on 3-amino-2-butanol and phthalic anhydride to generate N-(1-methyl-2-hydroxypropyl) phthalimide, respectively carrying out oxidation by two steps to form 3-phthalimide-2-oxo-butyraldehyde, and finally carrying out condensation on 3-phthalimide-2-oxo-butyraldehyde and thiosemicarbazide to obtain a target product. The 3-phthalimide-2-oxobutryaldehyde-1, 2-bis-thiosemicarbazide has obvious inhibition action on replication of herpes simplex I type (HSV-I) and II I type (HSV-II) viruses in tissue culture cells; at present, the 3-phthalimide-2-oxobutryaldehyde-1, 2-bis-thiosemicarbazide is mainly clinically used for treating skin diseases caused by herpesvirus and sexually transmitted diseases caused by human papillomavirus (HSV) and has good curative effect.