79514-29-7Relevant academic research and scientific papers
Synthesis method of tetramisole hydrochloride
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Paragraph 0034; 0036; 0037; 0039; 0040; 0042; 0043; 0045, (2020/06/02)
The invention discloses a synthesis method of tetramisole hydrochloride, and belongs to the technical field of veterinary drug and medicine bulk drug synthesis. According to the method, tetramisole issynthesized by using (S)-3-(2-hydroxy-2-phenethyl)-2-iminothiazolidinone hydrochloride as a reaction raw material, and is further subjected to acidifying and salt forming with hydrochloric acid to synthesize tetramisole hydrochloride; and the method comprises the following steps: taking hydrochloric acid as a solvent by (S)-3-(2-hydroxy-2-phenethyl)-2-iminothiazolidinone hydrochloride, adding chlorosulfonic acid into the system, adjusting the alkality, and filtering to obtain tetramisole free alkali; and adding hydrochloric acid into the tetramisole free alkali in an aqueous solution, acidifying, distilling, and crystallizing to obtain the tetramisole hydrochloride product. According to the method, chlorosulfonic acid is adopted for direct dehydration cyclization so as to effectively avoid impurity generation while two steps of chlorination cyclization reactions are combined into one, so that the synthetic route is shortened, the technological process is simplified, and the method hasgood industrial prospects.
