79514-49-1

Usage

Uses

Used in Research and Pharmaceutical Applications:
[(dimethylamino)(1-pyridin-2-ylethylidene)carbonohydrazonoyl]selanyl is used as a reagent in organic synthesis, where its unique structure and properties allow for the exploration of various reactions and potential biological activities. Its presence in the synthesis process can lead to the development of new compounds with specific applications.
Used in Catalyst Development:
The presence of the selanyl group in [(dimethylamino)(1-pyridin-2-ylethylidene)carbonohydrazonoyl]selanyl may impart interesting redox properties to the compound. This characteristic makes it a potential candidate for use in the development of new catalysts, which can be applied in various chemical reactions to increase their efficiency and selectivity.
Used in Drug Development:
As a pharmacophore, [(dimethylamino)(1-pyridin-2-ylethylidene)carbonohydrazonoyl]selanyl can be utilized in the development of new drugs. Its unique structure and properties can be exploited to design and synthesize novel drug candidates with potential therapeutic applications in various medical fields.
Used in the Chemical Industry:
In the chemical industry, [(dimethylamino)(1-pyridin-2-ylethylidene)carbonohydrazonoyl]selanyl can be employed as an intermediate or building block in the synthesis of more complex molecules. Its unique functional groups and redox properties can be harnessed to create new compounds with specific applications in various sectors, such as materials science, agrochemicals, and environmental chemistry.

Upstream product

• 79514-55-9 C₁₁H₁₆N₄S 
• 71555-14-1 2-acetylpyridine 4,4-dimethylthiosemicarbazone 

Relevant academic research and scientific papers

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

Selenosemicarbazones show marked antitumor activity. However, their mechanism of action remains unknown. We examined the medicinal chemistry of the selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone (Ap44mSe), and its iron and copper complexes to elucidate its mechanisms of action. Ap44mSe demonstrated a pronounced improvement in selectivity toward neoplastic relative to normal cells compared to its parent thiosemicarbazone. It also effectively depleted cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Significantly, Ap44mSe limited deleterious methemoglobin formation, highlighting its usefulness in overcoming toxicities of clinically relevant thiosemicarbazones. Furthermore, Cu-Ap44mSe mediated intracellular reactive oxygen species generation, which was attenuated by the antioxidant, N-acetyl-l-cysteine, or Cu sequestration. Notably, Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization. This investigation highlights novel structure-activity relationships for future chemotherapeutic design and underlines the potential of Ap44mSe as a selective anticancer/antimetastatic agent.

Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia

This invention relates to novel transition metal complexes of 2-acetyl- and-propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures u

2-acetyl- and 2-propionylpyridine selenosemicarbazones

This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.