79516-68-0 Usage
Originator
Livostin,Janssen-Cilag,Belgium
Uses
Anti histaminic.
Manufacturing Process
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by
addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base
catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is
synthesized an intermediate that after decarboethoxylation gives 1-(4-
fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5-
phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4-
oxycyclohexanecarbonitrile under reductive hydrogenation conditions
(palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4-
piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-
4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed
by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-
fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is
transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)
cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))-
(Levocabastine hydrochloride)
Brand name
Livostin (Novartis).
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 79516-68-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,5,1 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 79516-68:
(7*7)+(6*9)+(5*5)+(4*1)+(3*6)+(2*6)+(1*8)=170
170 % 10 = 0
So 79516-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1