79517-06-9Relevant academic research and scientific papers
Enantioselective chromatography in analysis of triacylglycerols common in edible fats and oils
Kalpio, Marika,Nylund, Matts,Linderborg, Kaisa M.,Yang, Baoru,Kristinsson, Bj?rn,Haraldsson, Gudmundur G.,Kallio, Heikki
, p. 718 - 724 (2015/02/02)
Enantiomers of racemic triacylglycerol (TAG) mixtures were separated using two chiral HPLC columns with a sample recycling system and a UV detector. A closed system without sample derivatisation enabled separation and identification by using enantiopure reference compounds of eleven racemic TAGs with C12-C22 fatty acids with 0-2 double bonds. The prolonged separation time was compensated for byfewer pretreatment steps. Presence of one saturated and one unsaturated fatty acid in the asymmetricTAG favoured the separation. Enantiomeric resolution, at the same time with stronger retention of TAGs,increased with increasing fatty acid chain length in the sn-1(3) position. Triunsaturated TAGs containingoleic, linoleic or palmitoleic acids did not separate. The elution order of enantiomers was determined bychemoenzymatically synthesised enantiopure TAGs with a co-injection method. The method is applicableto many natural fats and oils of low unsaturation level assisting advanced investigation of lipid synthesisand metabolism.
Stereospecific synthesis of selected triglycerides: comments on acyl migration and analysis of configuration
Sonnet, Philip E.,Dudley, Robert L.
, p. 185 - 191 (2007/10/02)
Symmetrical and stereospecifically defined triglycerides have been prepared from racemic and (R)- and (S)-glycidol, respectively.The synthetic sequence allows the incorporation of sensitive fatty acids such as linolenic acid.Justification for retention of
