795280-84-1Relevant articles and documents
Heterobimetallic gadolinium(III)-iron(III) complex of DTPA-bis(3- hydroxytyramide)
Parac-Vogt, Tatjana N.,Kimpe, Kristof,Binnemans, Koen
, p. 325 - 329 (2004)
A derivative of diethylenetriamine-N,N,N′,N″,N″- pentaacetic acid (DTPA), carrying two catechol functional groups has been synthesised by the reaction between DTPA-bis(anhydride) and 3-hydroxytyramine (dopamine). The ligand DTPA-bis(3-hydroxytyramide), [DTPA(HTA)2], is able to form stable heterobimetallic complexes with gadolinium(III) and iron(III) ions. The gadolinium(III) occupies the internal coordination cage of DTPA formed by three nitrogens, two carboxylate and two amide oxygens, while the [Fe(NTA)(H2O)2] (nitrilotriacetic acid, NTA) binds to catechol units by the substitution of two water ligands. The formation of polymeric species was avoided by using the tripodal NTA ligand. The heterobimetallic complex was characterised by means of visible absorption spectroscopy, electron spray ionisation-mass spectrometry (ESI-MS), and nuclear magnetic resonance (NMR) spectroscopy.
Bis(phenylethylamide) derivatives of Gd-DTPA as potential receptor-specific MRI contrast agents
Laurent, Sophie,Parac-Vogt, Tatjana N.,Kimpe, Kristof,Thirifays, Coralie,Binnemans, Koen,Muller, Robert N.,Vander Elst, Luce
, p. 2061 - 2067 (2008/02/09)
DTPA-bis(amide) derivatives bearing phenyl, phenol or catechol groups that mimic side chains of naturally occurring amino acids, such as phenylalanine, tyrosine or dopamine, were synthesized and characterized by elemental analysis, electrospray mass spect
