795300-72-0Relevant academic research and scientific papers
Synthesis of chiral β3-aminoxy peptides
Yang, Dan,Zhang, Yu-Hui,Li, Bing,Zhang, Dan-Wei
, p. 7577 - 7581 (2007/10/03)
A series of chiral β3-aminoxy acids or amides with various side chains have been synthesized via two different approaches. One is the Arndt-Eistert homologation approach, using chiral α-aminoxy acids as starting materials. The other approach, utilizing the enantioselective reduction of β-keto esters catalyzed by baker's yeast or chiral Ru(II) complexes, produces chiral β3-aminoxy acids with nonproteinaceous side chains. The oligomers of β3-aminoxy acids can be readily prepared using EDCI/HOAt as the coupling reagent.
