795306-57-9

Basic information

• Product Name: 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)-
• CAS NO: 795306-57-9
• Molecular Formula: C30H35F2NO3Si
• Molecular Weight: 523.695
• Mol File: 795306-57-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)-(795306-57-9)
• EPA Substance Registry System: 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-, (3R,4S)-(795306-57-9)

Safety Data

• Hazardous Substances Data: 795306-57-9(Hazardous Substances Data)

Upstream product

• 795306-53-5 Acetic acid 4-{(2S,3R)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-oxo-azetidin-2-yl}-phenyl ester 
• 179411-51-9 N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline 
• 3382-63-6 N-(4-hydroxybenzylidene)-4-fluorobenzenamine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 189028-95-3 (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one 
• 189028-93-1 (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione 
• 149437-76-3 5-(4-fluorophenyl)-5-oxopentanoic acid 
• 879005-60-4 (S)-(-)-1-(4’-fluorophenyl)but-3-en-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 163222-33-1 ezetemibe 
• 795306-55-7 Acetic acid 4-[(2S,3R)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenyl ester 

Downstream Products

• 795306-68-2 (3R,4S)-3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-[4-((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-phenyl]-azetidin-2-one 
• 795306-75-1 (3R,4S)-3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylmethoxy)-phenyl]-azetidin-2-one 
• 795306-61-5 acetic acid 4-acetoxy-6-acetoxymethyl-2-(4-{1-(4-fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-propyl]-4-oxo-azetidin-2-yl}-phenoxy)-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester 
• 163222-33-1 ezetemibe 
• 849799-29-7 ((2S,3S,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-methanesulfonic acid 4-[(2S,3R)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenyl ester 
• 849799-25-3 Methanesulfonic acid 4-[(2S,3S)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-azetidin-2-yl]-phenyl ester 
• 866918-10-7 Benzenesulfonic acid 4-{(2S,3R)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-oxo-azetidin-2-yl}-phenyl ester 
• 849799-26-4 Methanesulfonic acid 4-{(2S,3S)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-azetidin-2-yl}-phenyl ester 
• 849799-35-5 ((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-methanesulfonic acid 4-[(2S,3R)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenyl ester 
• 849799-37-7 ((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-methanesulfonic acid 4-[(2S,3S)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-azetidin-2-yl]-phenyl ester 
• 849799-30-0 ((2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-methoxy-tetrahydro-pyran-2-yl)-methanesulfonic acid 4-[(2S,3R)-3-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenyl ester 
• 849799-31-1 ((2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-methoxy-tetrahydro-pyran-2-yl)-methanesulfonic acid 4-{(2S,3R)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-oxo-azetidin-2-yl}-phenyl ester 

Relevant articles and documents

according to folds Mai Bu and its intermediate synthesis method

The invention provides an Ezetimibe synthesis method comprising the following steps: (a) a compound (5) is subjected to asymmetric reduction reaction to obtain a compound (6), and the compound (6) and tert-butyldimethylsilyl chloride react in an organic solution under the action of alkali to obtain a compound (7); (b) the compound (7) and diisopropylethylamine are dissolved in the organic solution, titanium tetrachloride is added in the organic solution to react at 20-50 DEG C, and a compound (3) is added in the organic solution at minus 20 to minus 60 DEG C to react to obtain a compound (8); (c) the compound (8) and N,O-bis(trimethylsilyl) acetamide react in the organic solution at 20-80 DEG C, tetrabutylammonium fluoride trihydrate is added into the organic solution to react at 20-80 DEG C to obtain a compound (9); (d) the compound (9) is subjected to off-protection reaction to obtain Ezetimibe, wherein R is equal to TBS, Ac or COOCH2CCl3. The invention further provides an Ezetimibe intermediate and a preparation method thereof.

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