795307-58-3Relevant academic research and scientific papers
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone
Carter, Percy H.,Brown, Gregory D.,King, Sarah R.,Voss, Matthew E.,Tebben, Andrew J.,Cherney, Robert J.,Mandlekar, Sandhya,Lo, Yvonne C.,Yang, Gengjie,Miller, Persymphonie B.,Scherle, Peggy A.,Zhao, Qihong,Decicco, Carl P.
scheme or table, p. 3311 - 3316 (2012/06/18)
We describe an isostere-driven approach to improve upon a previously-described series of capped dipeptide antagonists of CC Chemokine Receptor 2 (CCR2). Modification of the substitution around the isostere was combined with additional changes in a distal
