79537-08-9

Upstream product

• 127553-47-3 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 81246-80-2 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 79537-01-2 Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester 

Relevant academic research and scientific papers

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants

Cyclic dinucleotides (CDNs) are known to activate stimulator of interferon genes (STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence

Nucleotide. XV. Synthese und Eigenschaften von 2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytritylribonucleosid-3'-phosphotriestern, Ausgangssubstanzen fuer Oligonucleotid-Synthesen

The syntheses of two types of fully blocked ribonucleoside 3'-phosphotriesters 6-14 have been achieved in excellent yields from 2'-O-t-butyldimethylsilyl-5'-O-monomethoxytrityl-ribonucleosides 1-5 by phosphorylation with 2-chloro- and 2,5-dichlorophenylph