79544-27-7

Basic information

• Product Name: Benzonitrile,2-bromo-6-fluoro-
• Synonyms: 3-Bromo-2-cyanofluorobenzene
• CAS NO: 79544-27-7
• Molecular Formula: C₇H₃BrFN
• Molecular Weight: 200.0078
• Product Categories: Fluorine series;cyanide| alkyl bromide| alkyl Fluorine;Aromatic Nitriles;Nitrile;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 79544-27-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 58-62℃
• Boiling Point: 254.6 °C at 760 mmHg
• Flash Point: 107.8 °C
• Appearance: /
• Density: 1.69 g/cm³
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Benzonitrile,2-bromo-6-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile,2-bromo-6-fluoro-(79544-27-7)
• EPA Substance Registry System: Benzonitrile,2-bromo-6-fluoro-(79544-27-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R36/37/38:
• Safety Statements: S26:
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 79544-27-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white crystalline

InChI:InChI=1/C7H3BrFN/c8-6-2-1-3-7(9)5(6)4-10/h1-3H

Upstream product

• 1309606-36-7 N-[(2-bromo-6-fluorophenyl)methylidene]hydroxylamine 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 1073-06-9 3-fluorobromobenzene 
• 394-47-8 2-fluorobenzonitrile 
• 1897-52-5 2,6 difluorobenzonitrile 
• 77326-36-4 2-amino-6-fluorobenzonitrile 

Downstream Products

• 1219024-65-3 2-[2-(diphenylmethylene)hydrazino]-6-fluorobenzonitrile 
• 1619256-29-9 2-fluoro-6-(2-methylallyl)benzaldehyde 
• 1619256-49-3 C₂₀H₁₉FN₂ 
• 951893-85-9 2-fluoro-6-(2-methylallyl)benzonitrile 
• 342427-96-7 2-benzylamino-6-phenylbenzonitrile 

Relevant articles and documents

Preparation method of 2,6-dibromoaniline

The invention discloses a preparation method of 2,6-dibromoaniline. According to the method, 2,6-difluorobenzonitrile is used as an initial raw material, and the 2,6-dibromoaniline is synthesized through six steps of reactions including ammonolysis, diazotization bromination, re-ammonolysis, re-diazotization bromination, amidation and Hofmann degradation. The 2,6-dibromoaniline obtained in the process is a brown solid, and the purity of the 2,6-dibromoaniline is 98% or above.

Process for synthesizing 2-cyanogroup 3-fluorophenylboronic acid

The invention relates to a process for synthesizing 2-cyanogroup 3-fluorophenylboronic acid. According to the method, 3-bromofluorobenzene is used as a raw material, and takes a reaction with LDA and dimethylformamide in a tetrahydrofuran solvent to obtain 2-fluorine 6-bromobenzaldehyde; then, the 2-fluorine 6-bromobenzaldehyde and hydroxylamine hydrochloride take a reaction at 100 DEG C to obtain 2-fluorine 6-bromoxynil; finally, triisopropyl borate is added into the intermediate; n-butyllithium is dropwise added at -70 DEG C; reduced pressure distillation is performed to obtain 2-fluorine 6-bromophenylboronic acid. The process provided by the invention has the advantages that the operation is simple and convenient; the raw material can be easily obtained; the yield is high.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.