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79551-86-3

20-HETE, or 20-hydroxyeicosatetraenoic acid, is a cytochrome P450 (CYP450) metabolite derived from arachidonic acid. It consists of arachidonic acid bearing a hydroxy substituent at position 20 and may play an autacoid role in cerebral and renal vasculature.

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  • 79551-86-3 Structure

  • Basic information

    1. Product Name: 20-HETE
    2. Synonyms: 20-HETE, 20-Hydroxyarachidonic acid;20-HETE Lipid Maps MS Standard;20-Hydroxyeicosa-5Z,8Z,11Z,14Z-tetraenoic acid;omega-Hydroxyarachidonic acid;20-HYDROXY-(5Z,8Z,11Z,14Z)-EICOSATETRAENOIC ACID;20-HYDROXYARACHIDONIC ACID;20-HETE;20-Hydroxyarachlidonic acid
    3. CAS NO:79551-86-3
    4. Molecular Formula: C20H32O3
    5. Molecular Weight: 320.47
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 79551-86-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 482°C at 760 mmHg
    3. Flash Point: 14℃
    4. Appearance: /
    5. Density: 0.985g/cm3
    6. Vapor Pressure: 2.57E-11mmHg at 25°C
    7. Refractive Index: 1.514
    8. Storage Temp.: −20°C
    9. Solubility: N/A
    10. PKA: 4.75±0.10(Predicted)
    11. CAS DataBase Reference: 20-HETE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 20-HETE(79551-86-3)
    13. EPA Substance Registry System: 20-HETE(79551-86-3)

  • Safety Data

    1. Hazard Codes: F,Xi
    2. Statements: 11-36/37/38
    3. Safety Statements: 16-26-36
    4. RIDADR: UN 1170 3/PG 2
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 79551-86-3(Hazardous Substances Data)

79551-86-3 Usage

Uses

Used in Pharmaceutical Applications:
20-HETE is used as a bioactive compound for its potential role in the regulation of cerebral and renal vasculature. Its involvement in these processes makes it a promising candidate for the development of therapeutic agents targeting various vascular-related conditions.
Used in Research and Development:
20-HETE is used as a research tool for studying the mechanisms and pathways related to cerebral and renal vasculature. Understanding its role in these processes can contribute to the advancement of medical knowledge and the development of novel treatments for related diseases.
Used in Drug Delivery Systems:
Similar to gallotannin, 20-HETE can also be employed in drug delivery systems to enhance its applications and efficacy in targeting specific conditions. Various organic and metallic nanoparticles can be used as carriers for 20-HETE delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes in the context of cerebral and renal vasculature.

Biochem/physiol Actions

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.

Check Digit Verification of cas no

The CAS Registry Mumber 79551-86-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,5,5 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 79551-86:
(7*7)+(6*9)+(5*5)+(4*5)+(3*1)+(2*8)+(1*6)=173
173 % 10 = 3
So 79551-86-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-

79551-86-3 Well-known Company Product Price

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  • Sigma

  • (H3023)  20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid  ~100 μg/mL in ethanol, ≥90% (HPLC)

  • 79551-86-3

  • H3023-10UG

  • 2,215.98CNY

  • Detail

  • Sigma

  • (H3023)  20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid  ~100 μg/mL in ethanol, ≥90% (HPLC)

  • 79551-86-3

  • H3023-50UG

  • 8,815.95CNY

  • Detail

79551-86-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 20-HETE

1.2 Other means of identification

Product number -
Other names 20-hydroxyeicosatetraenoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:79551-86-3 SDS

79551-86-3Relevant articles and documents

Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism

El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.

, p. 1278 - 1288 (2016/04/26)

Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means

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