79558-90-0

Basic information

• Product Name: N¹-methyl-N²-(2-hydroxy-5-methylphenyl)thiourea
• CAS NO: 79558-90-0
• Molecular Weight: 196.273
• Mol File: 79558-90-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹-methyl-N²-(2-hydroxy-5-methylphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-methyl-N²-(2-hydroxy-5-methylphenyl)thiourea(79558-90-0)
• EPA Substance Registry System: N¹-methyl-N²-(2-hydroxy-5-methylphenyl)thiourea(79558-90-0)

Safety Data

• Hazardous Substances Data: 79558-90-0(Hazardous Substances Data)

Upstream product

• 556-61-6 methyl thioisocyanate 
• 95-84-1 3-amino-4-hydroxytoluene 

Downstream Products

• 22876-22-8 5-methylbenzo[d]oxazole-2-thiol 

Relevant articles and documents

STUDIES ON HETEROCYCLIC COMPOUNDS. XXXIV. SYNTHESIS OF 2-SUBSTITUTED AMINOBENZOXAZOLES WITH NICKEL PEROXIDE

Oxidation of N-methyl (or phenyl)-N'-(4-methylpyrid-2-yl)thiourea (Ia, b) with nickel peroxide (Ni-PO) under reflux in benzene or acetonitrile afforded the corresponding ureas (IIa, b).N-(2-Hydroxy-5-methylphenyl)-N'-methylthiourea (IVa) was synthesized by the reaction of 2-amino-4-methylphenol (III) and methyl isothiocyanate in benzene under reflux.Howevwer, the reaction of III and phenyl isothiocyanate in benzene under reflux did not afford the thiourea (IVb) but IVb was obtained in ethanol at room temperature.NiPO oxidation of thioureas (IVa-f) in acetonitrile at room temperature afforded 2-substituted aminobenzoxazoles (VIIa-f) in good yields.The reaction mechanisms of Ni-PO and thioureas (Ia, b and IVa-f) are discussed.Keywords: - N-substituted N'-(4-methylpyrid-2-yl)thioureas; N-substituted N'-(4-methylpyrid-2-yl)ureas; N-(2-hydroxyphenyl) N'-substituted thioureas; 2-substituted aminobenzoxazoles; nickel peroxide; oxidative cyclization; 2-mercaptobenzoxazole; isothiocyanates