79560-75-1Relevant academic research and scientific papers
Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors
Kang, Iou-Jiun,Wang, Li-Wen,Hsu, Tsu-An,Yueh, Andrew,Lee, Chung-Chi,Lee, Yen-Chun,Lee, Ching-Yin,Chao, Yu-Sheng,Shih, Shin-Ru,Chern, Jyh-Haur
, p. 1948 - 1952 (2011/05/04)
A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.
Synthesis of Spirothiadiazoline>-2-ones by Acetylation of Isatin-β-thiosemicarbazones
Somogyi, Laszlo
, p. 931 - 934 (2007/10/02)
The synthesis of spirothiadiazoline>-2-ones 2a-g by cyclization of isatin-β-thiosemicarbazones 1a-f is reported.The structure determination of 2a-g by IR, (1)H- and (13)C-NMR measurements is also described. Key words: Acetylation; isatin; 1,3,4-thiadiazolines; thiosemicarbazones, cyclization of
Syntheses of some substituted isatin-β-thiosemicarbazones and isatin-β-hydrazonothiazoline derivatives as potential antiviral and antimicrobial agents
Omar,Eshba,Salama
, p. 701 - 709 (2007/10/02)
A series of isatin-β-thioxemicarbazones and isatin-β-hydrazonothiazolines was synthesized by condensation of various isatin derivatives with N4-substituted-3-thiosemicarbazides and cyclization of the products by phenacyl bromides. The products
Reactions of 3-Arylimino-2-Indolinones with p-Substituted Phenylthiosemicarbazides
Varma, Rajendra S.,Garg, Pradeep K.
, p. 980 - 981 (2007/10/02)
3-Arylimino-2-indolinones (II) have been prepared by the condensation of isatins (I) with anilines.Reactions of II with p-substituted phenylthiosemicarbazides have resulted (in every instance) in the displacement of arylimino groups by the phenylthiosemic
