79564-23-1Relevant academic research and scientific papers
A simple one-pot methodology for the synthesis of substituted benzoylguanidines from benzoylthioureas using tert-butyl hydroperoxide
Esteves, Henrique,De Fátima, ?ngelo,Castro, Rosane De P.,Sabino, José R.,MacEdo, Fernando,Brito, Tiago Oliveira
, p. 6872 - 6874 (2015/11/27)
The potential of tert-butyl hydroperoxide as a reagent in the guanylation of benzoylthioureas in the presence of amines has been evaluated in a systematic study involving substrates bearing N2-substituents with different electronic properties. The results show that tBuOOH is a suitable and robust reagent for the synthesis of either N1,N2,N3-tri- and tetrasubstituted or N1,N2-disubstituted guanidines from N2-substituted N1-benzoylthioureas and N1-benzoylthioureas, respectively. The recrystallised guanylation adducts were readily obtained in good yields and at high purity levels after a simple one-pot reaction procedure. The crystal structures of two novel benzoylguanidines are provided.
Alkylation of Thioureas and Related Compounds by Use of Alcohols, Diethyl Azodicarboxylate, and Triphenylphosphine
Nagasawa, Hiroshi,Mitsunobu, Oyo
, p. 2223 - 2224 (2007/10/02)
The alkylation of ambident nucleophiles having a thiocarbonyl group by use of alcohols, diethyl azodicarboxylate, and triphenylphosphine was studied.Selective S-alkylation took place in the cases of N-benzoyl-N'-mono- and -disubstituted thioureas, while s
