79568-06-2Relevant academic research and scientific papers
Preparation and evaluation of arylazide-substituted pyridine adenine dinucleotides for photoaffinity labeling experiments
Liu, Wenqiu,Gaines, Michelle,Bao, Rong,Clifford, Jacquelynn,Li, Yuzhou
, p. 793 - 799 (2007/10/03)
Two pyridine-modified NAD + analogs, 3-(3-azido benzoyl) pyridine adenine dinucleotide 1 and N-(S-azido-5-carboxyl) phenyl nicotinamide adenine dinucleotide 2 have been prepared and evaluated for photoaffinity labeling experiments. The syntheses were acco
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake
Hogberg,Ulff,Renyi,Ross
, p. 1499 - 1507 (2007/10/02)
Analogues of the antidepressant agent zimelidine [6, (Z)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine], a selective inhibitor of neuronal 5-hydroxytryptamine reuptake, were synthesized by several routes with the aim of obtaining compounds having a cis configuration (with respect to pyridyl and allylamine). Two methods utilized suitably substituted benzoylpyridines as starting materials. In two other routes, the bromine in 6 was either directly displaced (CN) or converted via the corresponding lithio derivative to H, Cl, I, Me, SiMe3. The configurations were determined by UV, 1H NMR and lanthanide-induced shifts in 1H NMR. The compounds were evaluated as uptake inhibitors by measuring the accumulation of [3H]noradrenaline and 5-hydroxyl[14C]tryptamine in mouse brain slices (in vitro and in vivo). Para substitution favored 5-hydroxytryptamine activity and ortho substitution favored NA activity in the cis series. The in vitro effect on 5-hydroxytryptamine was rather insensitive to variations in the para substituent, whereas pronounced effects in vivo were observed only with Cl, Br (6), and I.
