79600-35-4Relevant academic research and scientific papers
A conjugate Lewis base-Br?nsted acid catalyst for the sulfenylation of nitrogen containing heterocycles under mild conditions
Nalbandian, Christopher J.,Miller, Eric M.,Toenjes, Sean T.,Gustafson, Jeffery L.
supporting information, p. 1494 - 1497 (2017/02/05)
Catalysts that contain a thiourea tethered to a carboxylic acid were found to affect the sulfenylation of indoles and other N-heterocycles on the hour time scale at room temperature. The mild nature of these conditions allowed for the incorporation of diverse functionalities into more complex heterocycles.
Mild synthesis of N -acylsulfenamides from arylamides and disulfides
Zhang, Xing-Song,Zhang, Xiao-Hong
, p. 89 - 94 (2016/01/25)
An efficient and new method was developed to synthesize N-acylsulfenamides via NaH-promoted sulfenylation of benzamides with readily available disulfides under mild conditions. A series of N-acylsulfenamides were easily obtained in moderate to high yields. Moreover, the obtained N-acylsulfenamides were used as thiolating reagents in the synthesis of sulfenylpyrroles and 3-sulfenylbenzofurans.
Cs2CO3 promoted direct C-H bond sulfenylation of imidazo[1,2-a]pyridines and related heteroarenes in ionic liquid
Gao, Zhaochang,Zhu, Xun,Zhang, Ronghua
, p. 19891 - 19895 (2014/05/20)
An efficient and novel method was developed for the synthesis of 3-sulfenyl imidazo[1,2-a]pyridines in good to excellent yields via a Cs2CO 3 promoted direct sulfenylation of imidazo[1,2-a]pyridines. The reaction proceeds smoothly with a wide range of structurally diverse heteroarenes and disulfides. This protocol is environmentally friendly because it is free of transition-metal catalysts and utilizes aryl-substituted imidazolium-based ionic liquid rather than volatile organic solvents.
Facile carbon-sulfur bond cleavage in diarylsulfonium ylides: A catalytic sulfur-to-silicon group transfer
Huang, Xueliang,Goddard, Richard,Maulide, Nuno
supporting information, p. 4292 - 4294 (2013/05/23)
An unusual cleavage of the non-ylidic carbon-sulfur bond of a sulfonium ylide is reported. The reaction can be catalysed by a variety of palladium(ii) complexes under mild conditions. Preliminary results show that coordination of the ylide to the metal center results in significant structural changes.
Copper-catalyzed sulfenylation of pyrroles with disulfides or thiols: Directly synthesis of sulfenyl pyrroles
Alves, Diego,Lara, Renata G.,Contreira, Maria E.,Radatz, Cátia S.,Duarte, Luis F.B.,Perin, Gelson
experimental part, p. 3364 - 3368 (2012/07/28)
We present here the synthesis of sulfenyl pyrroles by copper-catalyzed sulfenylation of pyrroles with organic disulfides or thiols. The direct sulfenylation of pyrroles with organic disulfides has been accomplished in the presence of 3 mol % of CuI in DMS
Preparation of sulfenyl pyrroles
Gillis, H. Martin,Greene, Lana,Thompson, Alison
experimental part, p. 112 - 116 (2009/06/18)
Sulfenyl groups are attracting interest as masking/protecting groups for pyrroles. A facile one-step synthesis of sulfenyl pyrroles, involving the reaction of pyrroles with N-(aryl- and alkylthio)phthalimides in the presence of MgBr2, is reported and the methodology extends to include sulfinyl pyrroles. The one-step procedure gives good yields and is more efficient and practical than current multistep protocols to sulfenyl pyrroles that involve thiocyanato pyrrolic intermediates. A convenient procedure for the synthesis of N-(aryl- and alkylthio)phthalimides is also reported. Georg Thieme Verlag Stuttgart.
Asymmetric oxidation of 2-(arylsulfenyl)pyrroles
Thompson, Alison,Garabatos-Perera, Jose R.,Gillis, H. Martin
, p. 676 - 681 (2008/12/21)
The asymmetric oxidation of prochiral 2-(arylsulfenyl)pyrroles has been investigated. A marked electronic effect within the substrate significantly influenced the degree of enantioselectivitv obtained, with very high enantio-selectivity being obtained for
Geometric synthesis of porphyrin rods
-
Page/Page column 17-18, (2010/11/27)
A method of making a compound of Formula I′ comprises reacting a compound of the formula DLCHO, with a compound of the formula to produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.
Accelerated arene ligand exchange in the (arene)Cr(CO)2L series
Semmelhack,Chlenov, Anatoly,Ho, Douglas M.
, p. 7759 - 7773 (2007/10/03)
Arene ligand exchange in the (η6-arene)Cr(CO)2L series can be accelerated if the ligand L is an electronically unsymmetrical bidentate ligand. The system evaluated here employs derivatives of tris(pyrrolyl)-phosphine as L. A series of 2-L′-substituted pyrroles was prepared, where the substituents include: L′= -SMe, -CH2SMe, -SPh, -CH2SPh, -SCF3, -S-tBu, -CO2Me, -CONMe2, -2-pyridinyl, and -PPh2. Reaction with CIP(pyrrolyl)2 gave a new series of phosphines, (2-L′-pyrrolyl) (pyrrolyl)2P. Each of these phosphines was converted to (arene)Cr(CO)2[P(2-L′-pyrrolyl)(pyrrolyl)2P) complexes. The substituents L′ are proposed to provide temporary coordination to the Cr and to lower the barrier to arene exchange. The series was evaluated where the arene in the complex (departing) is benzene, fluorobenzene, toluene, o-oxylene, m-xylene, or p-xylene and the incoming arene is C6D6, chlorobenzene-d5, anisole-d 8, fluorobenzene-d5, toluene-d8, o-oxylene-d10, m-xylene-d10, p-xylene-d10, or mesitylene-d12. Most of the new complexes showed a significant increase in the rate of arene exchange due to the side chain unit L′. The strongest effects were seen with the examples where X = -CO2Me, -CONMe2, and -(2-pyridinyl), allowing exchange with a half lifetime as low as 8 h/22 °C.
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure
Campiani, Giuseppe,Nacci, Vito,Bechelli, Susanna,Ciani, Silvia M.,Garofalo, Antonio,Fiorini, Isabella,Wikstr?m, H?kan,De Boer, Peter,Liao, Yi,Tepper, Pieter G.,Cagnotto, Alfredo,Mennini, Tiziana
, p. 3763 - 3772 (2007/10/03)
The development of a synthetic approach to the novel pyrrolo[2,1- b][1,3]benzothiazepine and its derivatives and their biological evaluation as potential antipsychotic drugs are described. In binding studies these compounds proved to be potent 5-HT2
