796047-30-8

Basic information

• Product Name: 3β-tosyl-pregna-5-en-20-dithane
• Synonyms: 3β-tosyl-pregna-5-en-20-dithane
• CAS NO: 796047-30-8
• Molecular Weight: 574.913
• Mol File: 796047-30-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3β-tosyl-pregna-5-en-20-dithane(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-tosyl-pregna-5-en-20-dithane(796047-30-8)
• EPA Substance Registry System: 3β-tosyl-pregna-5-en-20-dithane(796047-30-8)

Safety Data

• Hazardous Substances Data: 796047-30-8(Hazardous Substances Data)

Upstream product

• 188955-65-9 3β-tert-butyldimethylsilyloxy-(20R)-20-hydroxy-pregna-5-en-dithiane 
• 188955-66-0 (20R)-20,3β-dihydroxy-20-dithianepregna-5-ene 
• 796047-29-5 3β-hydroxy-pregna-5-en-20-dithane 
• 98-59-9 p-toluenesulfonyl chloride 
• 979-02-2 16-dehydropregnenolone acetate 
• 58701-45-4 3β-t-butyldimethylsilyloxy-pregn-5-en-20-one 
• 1778-02-5 Pregnenolone acetate 
• 145-13-1 Pregnenolone 
• 920512-47-6 acetic acid 17-(1-[1,3]dithian-2-yl-1-hydroxy-ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 796047-25-1 3-β-tert-butyldimethylsilyloxy-pregna-5-en-20,22-ketene-dithioacetal 
• 796047-27-3 3β-acetoxy-pregna-5-en-20,22-ketene-dithioacetal 
• 796047-28-4 3β-acetoxy-pregna-5-en-20-dithane 
• 796047-26-2 3-β-hydroxy-pregna-5-en-20,22-ketene-dithioacetal 

Relevant articles and documents

Stereoselective syntheses of 20-epi cholanic acid derivatives from 16-dehydropregnenolone acetate

A stereoselective total synthesis of naturally occurring 20-epi cholanic acid derivatives has been realized, starting from readily available 16-dehydropregnenolone acetate. The key step of these syntheses involves an ionic hydrogenation of a C-20,22-ketene dithioacetal and deoxygenation of steroidal C-20 tert-alcohols, to set up the unnatural C(20R) configuration with 100% stereoselectivity. The unnatural C-22 aldehydes with C(20R) stereocenters thus obtained were elaborated to 20-epi cholanic acid derivatives. Two derivatives of 20-epi cholanic acid were synthesized and their structures have been confirmed by single crystal X-ray analysis. Catalytic hydrogenation of 16-dehydropregnenolone acetate and 16-dehydropregnenolone in ethanol affords C-5,C-16 tetrahydro products. Crystal structure analysis of one of these products revealed C-5α and C-17α configurations of the hydrogen atoms.