79610-67-6

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 105-07-7 4-cyanobenzaldehyde 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 19311-91-2 N,N-diethylsalicylamide 

Downstream Products

• 92831-00-0 4-(4-cyanophenyl)-5-(2-hydroxybenzoyl)-1,2,3-triazole 
• 92831-10-2 3-amino-4'-cyanoflavone 
• 92830-97-2 5-(2-hydroxyphenyl)-3-(4-cyano-phenyl)-isoxazole 
• 97871-90-4 (Z)-4-((3-oxobenzofuran-2(3H)-ylidene)methyl)benzonitrile 
• 92830-85-8 4-cyano-2'-hydroxychalcone dibromide 

Relevant academic research and scientific papers

Iodine-mediated direct synthesis of 3-iodoflavones

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

From Carbamate to Chalcone: Consecutive Anionic Fries Rearrangement, Anionic Si → C Alkyl Rearrangement, and Claisen-Schmidt Condensation

A highly efficient one-pot procedure was developed for the synthesis of various 2′-hydroxychalcones from phenyl diethylcarbamate, featuring consecutive Snieckus-Fries rearrangement, anionic Si a?' C alkyl rearrangement, and Claisen-Schmidt condensation in a single operation. The applicability of this protocol was demonstrated by the highly efficient synthesis of the anti-inflammatory natural product lonchocarpin. The mechanism insight is also provided.

Red fluorescence from tautomers of 2′-hydroxychalcones induced by intramolecular hydrogen atom transfer

Tautomer fluorescence in the longer wavelength region at 600 nm produced by intramolecular hydrogen atom transfer was observed in several 2′-hydroxychalcones having an electron donating group at the para position of the phenyl ring. The quantum yield of tautomer fluorescence increased by 1000 times upon decreasing the temperature from room temperature to 77 K. The introduction of dendritic substituents also increased the intensity of the tautomer fluorescence. One can control the photochemical and photophysical properties of the olefins by introduction of intramolecular hydrogen bonding and photoinduced hydrogen atom transfer. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2009.