79645-01-5

Basic information

• Product Name: 1,3-dimethyl-1-nitrosothiourea
• Synonyms: N-Nitrosodimethylthiourea
• CAS NO: 79645-01-5
• Molecular Formula: C₃H₇N₃OS
• Molecular Weight: 133.1722
• Mol File: 79645-01-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 154.8°C at 760 mmHg
• Flash Point: 47.4°C
• Density: 1.26g/cm³
• Vapor Pressure: 3.12mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 1,3-dimethyl-1-nitrosothiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-1-nitrosothiourea(79645-01-5)
• EPA Substance Registry System: 1,3-dimethyl-1-nitrosothiourea(79645-01-5)

Safety Data

• Hazardous Substances Data: 79645-01-5(Hazardous Substances Data)

Usage

Chemical class

Nitrosothiourea

Structural components

Contains a nitroso group and a thiourea moiety

Primary use

Research as a carcinogen and mutagen

Potential effects

Causes cancer and genetic mutations

Areas of study

DNA damage and effects on biological processes

Industrial and commercial applications

Not widely used due to toxicity and health risks

Handling precautions

Handled with caution

Ongoing research

Precise mechanism of action and specific toxicological properties

Upstream product

• 534-13-4 N,N-dimethylthiourea 

Downstream Products

• 2740-94-5 1-methyl-3-benzyl thiourea 
• 2489-77-2 1,1,3-trimethylthiourea 
• 13120-04-2 methyl-1 cyclohexyl-3 thio-2 uree 
• 534-13-4 N,N-dimethylthiourea 
• 556-61-6 methyl thioisocyanate 
• 13256-32-1 1,3 dimethyl 1 nitrosourea 
• 96-31-1 N,N'-Dimethylurea 

Relevant articles and documents

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Electronic and Steric Effects of Alkyl Group on Denitrosation of 3-Alkyl-1-methyl-1-nitrosothioureas

A series of 3-alkyl-1-methyl-1-nitrosothioureas with R=CH3, C2H5, cyclo-C6H11 (3), (CH3)2CH (4), C2H5(CH3)CH, and (CH3)3C were synthesized and their rates of acid catalyzes (pHH:kD is 1.25 for 4.Except 3, a linear plot of log kR/kMe for the denitrosation of RNHCSN(NO)CH3 vs. ?* provides ρ*=-0.98(r=-0.997).The significant factor affecting the rate determining step of the denitrosation of these N-nitrosothioureas at pH 4.6 is the electronic effect of the substituent at the N3 position.

Stereoelectronic control in the aqueous decomposition of novel nitrosothioureas

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