79669-46-8

Upstream product

• 68485-53-0 4-allyl-1-(1-hydroxy-1-benzyloxycarbonylmethyl)-azetidin-2-one 
• 68485-52-9 4-allylazetidin-2-one 
• 52709-42-9 benzylglyoxylate 
• 591-93-5 1,4-Pentadiene 

Downstream Products

• 79669-39-9 4-allyl-1-azetidin-2-one 
• 79683-54-8 (2RS,6RS)-benzyl 4-methyl-8-oxo-1,3-diazabicyclo<4.2.0>oct-3-ene-2-carboxylate 
• 79683-54-8 (2RS,6SR)-benzyl 4-methyl-8-oxo-1,3-diazabicyclo<4.2.0>oct-3-ene-2-carboxylate 
• 112213-53-3 (2RS,6SR)-4-methyl-8-oxo-1,3-diazabicyclo<4.2.0>oct-3-ene-2-carboxylic acid 
• 72658-70-9 benzyl 7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 72658-70-9 benzyl 7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 67501-71-7 benzyl 7-oxo-1-azabicyclo[3.2.0] hept-2-ene-2-carboxylate 
• 68485-45-0 4-allyl-1-(1-benzyloxycarbonyl-1-triphenylphosphoranylidenemethyl)-azetidin-2-one 
• 79683-54-8 (2S,6R)-4-Methyl-8-oxo-1,3-diaza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of Novel Fused β-Lactams by Intramolecular 1,3-Dipolar Cycloadditions. Part 9. Preparation of the 7-Oxo-1,3-dizabicycloheptane-2-carboxylate and 8-Oxo-1,3-dizabicyclooctane-2-carboxylate Ring Systems

4-Vinylazetidin-2-one (24) has been converted into 1--4-vinylazetidin-2-one (27) and 1--4-(2-methoxycarbonylvinyl)-azetidin-2-one (43) which on thermolysis in toluene gave (2RS,5RS)-ben

Olivanic Acid Analogues. Part 1. Total Synthesis of the 7-Oxo-1-azabicyclohept-2-ene-2-carboxylate System and Some Related β-Lactams

4-Allylazetidin-2-one, prepared from penta-1,4-diene and chlorosulphonyl isocyanate, has been used to synthesise the parent 7-oxo-1-azabicyclohept-2-ene-2-carboxylate system of the naturally occurring olivanic acids, using an intramolecular Wittig reaction to construct the 2,3-double bond.Cyclisation of ketones derived from the 4-allyl grouping produced 3-substituted derivatives, while use of the azetidin-2-one prepared from hexa-1,5-diene and chlorosulphonyl isocyanate has given the homologous 8-oxo-1-azabicyclooct-2-ene system.

SYNTHESES OF AZAPENEM AND AZACEPHEM RING SYSTEM

Novel β-lactam ring systems, 7-oxo-1,3-diazabicyclohept-3-ene(III), 7-oxo-1,4-diazabicyclohept-3-ene(IV), and 8-oxo-1,3-diazabicyclooct-3-ene(V) have been synthesized via cyclization of olefinic azide.