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3-Chloro-2-fluoro-4-iodopyridine is a heterocyclic aromatic compound with the molecular formula C5H2ClFIN. It features a pyridine ring to which chlorine, fluorine, and iodine atoms are attached, making it a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals. Known for its reactivity and potential in the development of new drugs, 3-Chloro-2-fluoro-4-iodopyridine serves as a building block for more complex molecules in the field of organic chemistry.

796851-05-3

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796851-05-3 Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-fluoro-4-iodopyridine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-2-fluoro-4-iodopyridine is utilized as a precursor in the production of pesticides and other agrochemicals, contributing to the creation of effective solutions for crop protection and management.
Used in Organic Chemistry Research:
3-Chloro-2-fluoro-4-iodopyridine is employed as a building block in organic chemistry for the construction of more complex molecules. Its versatility in participating in various chemical reactions makes it a valuable compound for research and development purposes, enabling the exploration of novel chemical pathways and the synthesis of innovative compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 796851-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,6,8,5 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 796851-05:
(8*7)+(7*9)+(6*6)+(5*8)+(4*5)+(3*1)+(2*0)+(1*5)=223
223 % 10 = 3
So 796851-05-3 is a valid CAS Registry Number.

796851-05-3Upstream product

796851-05-3Relevant articles and documents

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING ACTIVITY OF SHP2

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Paragraph 00155; 00160-00161, (2022/02/06)

Provided herein is a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme, wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI, wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.

Aryl spiro compound containing formamidine as well as preparation method and application of aryl spiro compound

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Paragraph 0061-0064, (2021/08/14)

The invention belongs to the field of medicinal chemistry, and particularly relates to an aryl spiro compound containing formamidine as well as a preparation method and application of the aryl spiro compound. The invention relates to three aryl spiro compounds as shown in general formulas I-III and pharmaceutically acceptable salts, enantiomers, non-isomers, tautomers, solvates, polymorphic substances or prodrugs thereof. On the basis that SHP099 is used as a lead compound, a brand new compound with guanidyl at the tail end is prepared, and the problems that an existing SHP2 inhibitor is single in structural framework and the like are solved. The aryl spiro compound has the important significance of providing many modification sites and providing a basis for later structural modification. Meanwhile, the embodiment of the invention proves that the compound has an allosteric inhibition effect on SHP2 phosphatase, and a skeleton support is provided for subsequent development of an SHP2 phosphatase inhibitor.

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

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Paragraph 00237-00238, (2020/05/12)

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2

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Paragraph 00308-00310; 00323; 00326, (2020/05/12)

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II wit

Deprotonation of chloropyridines using lithium magnesates

Awad, Ha?an,Mongin, Florence,Trécourt, Fran?ois,Quéguiner, Guy,Marsais, Francis

, p. 7873 - 7877 (2007/10/03)

Chloropyridines are deprotonated using lithium magnesates. 4-Chloropyridine was deprotonated on treatment with 1/3 equiv of the highly coordinated magnesate Bu3(TMP)MgLi2 in THF at -10°C, as evidenced by trapping with I2. The use of Bu(TMP)2MgLi in Et 2O allowed the reaction of 2-chloropyridine, giving the 3-functionalized derivative as the main product. Mixtures of 3- and 4-functionalized derivatives were obtained when 2,6-dichloropyridine was involved in the reaction. Performing the reaction on 3-chloropyridine with lithium magnesates in THF, either the 4,4′-dimer or the 4-iodo derivative was formed after quenching by I2, the former using 1/3 equiv of Bu2(TMP)MgLi and the latter using 1 equiv of (TMP)3MgLi. Similar results were observed with 3,5-dichloropyridine, 2,5-dichloropyridine and 3-chloro-2-fluoropyridine. 1,2-Migration of the lithium arylmagnesate formed by deprotonation was proposed to justify the dimers formation.

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