796851-05-3

Basic information

• Product Name: 3-Chloro-2-fluoro-4-iodopyridine
• Synonyms: 3-Chloro-2-fluoro-4-iodopyridine;2 - fluoro-3 - chloro-4 - Iodopyridine;Pyridine, 3-chloro-2-fluoro-4-iodo-
• CAS NO: 796851-05-3
• Molecular Formula: C5H2ClFIN
• Molecular Weight: 257.4319532
• Mol File: 796851-05-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-99 °C
• Boiling Point: 254.8±35.0 °C(Predicted)
• Appearance: /
• Density: 2.129±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -4.10±0.18(Predicted)
• CAS DataBase Reference: 3-Chloro-2-fluoro-4-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-fluoro-4-iodopyridine(796851-05-3)
• EPA Substance Registry System: 3-Chloro-2-fluoro-4-iodopyridine(796851-05-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 796851-05-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-2-fluoro-4-iodopyridine is a chemical compound with the molecular formula C5H2ClFIN. It is a heterocyclic aromatic compound that contains chlorine, fluorine, and iodine atoms attached to a pyridine ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its potential applications in the development of new drugs and for its use in the field of organic chemistry as a building block for more complex molecules. Additionally, 3-Chloro-2-fluoro-4-iodopyridine is known for its reactivity and ability to participate in various chemical reactions, making it a versatile compound for research and development purposes.

Upstream product

• 1480-64-4 3-chloro-2-fluoropyridine 

Downstream Products

• 1227603-07-7 3-chloro-4-iodo-2-methoxypyridine 

Relevant articles and documents

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING ACTIVITY OF SHP2

Provided herein is a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme, wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI, wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

Deprotonation of chloropyridines using lithium magnesates

Chloropyridines are deprotonated using lithium magnesates. 4-Chloropyridine was deprotonated on treatment with 1/3 equiv of the highly coordinated magnesate Bu3(TMP)MgLi2 in THF at -10°C, as evidenced by trapping with I2. The use of Bu(TMP)2MgLi in Et 2O allowed the reaction of 2-chloropyridine, giving the 3-functionalized derivative as the main product. Mixtures of 3- and 4-functionalized derivatives were obtained when 2,6-dichloropyridine was involved in the reaction. Performing the reaction on 3-chloropyridine with lithium magnesates in THF, either the 4,4′-dimer or the 4-iodo derivative was formed after quenching by I2, the former using 1/3 equiv of Bu2(TMP)MgLi and the latter using 1 equiv of (TMP)3MgLi. Similar results were observed with 3,5-dichloropyridine, 2,5-dichloropyridine and 3-chloro-2-fluoropyridine. 1,2-Migration of the lithium arylmagnesate formed by deprotonation was proposed to justify the dimers formation.