796856-92-3Relevant academic research and scientific papers
5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa
Batt, Douglas G.,Qiao, Jennifer X.,Modi, Dilip P.,Houghton, Gregory C.,Pierson, Deborah A.,Rossi, Karen A.,Luettgen, Joseph M.,Knabb, Robert M.,Jadhav,Wexler, Ruth R.
, p. 5269 - 5273 (2007/10/03)
Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa. Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors
Han,Dominguez,Stouten,Park,Duffy,Galemmo Jr.,Rossi,Alexander,Smallwood,Wong,Wright,Luettgen,Knabb,Wexler
, p. 4398 - 4415 (2007/10/03)
Thrombotic diseases are a major cause of death and morbidity. Factor Xa (fXa) plays a vital role in the regulation of normal homeostasis and abnormal intravascular thrombus development in the blood coagulation cascade. A novel series of fXa inhibitors inc
