796860-41-8

Upstream product

• 72-80-0 chloroquinaldol 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1415222-54-6 C₃₅H₂₄Cl₅NO₂PRe 
• 1415222-58-0 C₃₅H₂₄Br₂Cl₃NO₂PRe 

Relevant academic research and scientific papers

The synthesis and anticancer activity of 2-styrylquinoline derivatives. A p53 independent mechanism of action

A series of styrylquinolines was designed and synthesized based on the four main quinoline scaffolds including oxine, chloroxine and quinolines substituted with a hydroxyl group or chlorine atom at the C4 position. All of the compounds were tested for the

Design, synthesis and in Vitro activity of anticancer styrylquinolines. The p53 independent mechanism of action

A group of styrylquinolines were synthesized and tested for their anti-proliferative activity. Anti-proliferative activity was evaluated against the human colon carcinoma cell lines that had a normal expression of the p53 protein (HCT116 p53+/+

Novel oxorhenium(V) complexes of 8-hydroxyquinoline derivatives-Synthesis, spectroscopic characterization, X-ray crystal structures and DFT calculations

Two modifications of 8-hydroxyquinoline framework, namely 5,7-dichloro-2-[2-(2-chlorophenyl)vinyl]quinoline-8-ol (HL1) and 2-[2-(3,4-dichlorophenyl)vinyl] quinoline-8-ol (HL2) have been synthesized and their interaction with [ReOX3(PPh3) 2] (X = Cl, Br) have been examined. HL1 and HL2 react with [ReOX3(PPh3)2] to give [ReOCl 2(L1)(PPh3)]2·MeCN (1), [ReOBr2(L1)(PPh3)] (2), [ReOCl 2(L2)(PPh3)] (3) and [ReOBr2(L 2)(PPh3)] (4). The complexes have been characterized spectroscopically and structurally. The experimental studies on 1 and 3 have been accompanied by DFT calculations, and additional information about binding between the rhenium atom and oxo ligand has been obtained by NBO analysis. The X-ray studies and NBO analysis confirm a triple bond between the rhenium and the terminal oxo ligand. The L1 and L2 ligands coordinate in a chelate way via N- and O-donor atoms, and the oxygen donor of the chelate ligand is located trans to the terminal oxo (Ot) group due to a strong trans-influence of Ot ligand. DFT and TD-DFT calculations applied to 1 and 3 resulted in appropriate prediction of the UV-Vis spectra and enabled a detailed assignment of the electronic transitions to the experimental absorptions.

Contribution to investigation of antimicrobial activity of styrylquinolines

Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed again