79690-78-1Relevant academic research and scientific papers
2-(N-SUBSTITUTED GUANIDINO)-4-HETERO-ARYLTHIAZOLE ANTIULCER AGENTS
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, (2008/06/13)
2,4-Disubstituted thiazole compounds of the formula STR1 or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, orX is S and Y is CH;R 1 is certain straight or branched chain alkyl groups, (R 3) 2 C 6 H 3, or (R 3) 2 Ar(CH 2) n where n is an integer from 1 to 4, R 3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R 2 is H or (C 1-C 4)alkyl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R 4 is H, (C 1-C 5)alkyl, NH 2 or CH 2 OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.
The Synthesis of 2-Heteroarylimidazopyridin-3-ols and Related Compounds
Deady, Leslie W.,Stanborough, Mark S.
, p. 1295 - 1302 (2007/10/02)
A reaction between pyridin-2-amine 1-oxides and phenalcyl bromides has been extended to some bromoacetyl heteroaromatic compounds to form the title compounds.The reaction of some 2-aminodiazine 1-oxides with phenacyl bromides has also been studied.The imidazopyrimidne and imidazophthalazine systems have been prepared but reaction of pyrazin-2-amine 1-oxide did not give the desired cyclization.
