796964-11-9Relevant academic research and scientific papers
Palladium catalyzed indolization of 2-bromo or chloroanilines
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Page/Page column 11, (2010/02/14)
The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I) wherein: X, R and R1 are defined herein
The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: A new approach to 2,3-disubstituted indoles
Shen, Ming,Li, Guisheng,Lu, Bruce Z.,Hossain, Azad,Roschangar, Frank,Farina, Vittorio,Senanayake, Chris H.
, p. 4129 - 4132 (2007/10/03)
(Chemical Equation Presented) The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.
