797035-11-1

Basic information

• Product Name: BETA-SECRETASE INHIBITOR IV
• Synonyms: BETA-SECRETASE INHIBITOR IV;1,3-BENZENEDICARBOXAMIDE, N1-[(1S,2R)-3-(CYCLOPROPYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N3-[(1R)-1-PHENYLETHYL]-;N-((1S,2R)-1-BENZYL-3-CYCLOPROPYLAMINO-2-HYDROXY-PROPYL)-5-(METHANESULFONYL-METHYL-AMINO)-N'-((R)-1-PHENYL-ETHYL)-ISOPHTHALAMIDE;BACE-1 inhibitor;N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-(N-methylmethylsulfonamido)-N3-((R)-1-phenylethyl)isophthalamide;β-Secretase Inhibitor IV;3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
• CAS NO: 797035-11-1
• Molecular Formula: C31H38N4O5S
• Molecular Weight: 578.72
• Product Categories: Human β-secretase (BACE-1) inhibitor.
• Mol File: 797035-11-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 13.72±0.46(Predicted)
• CAS DataBase Reference: BETA-SECRETASE INHIBITOR IV(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-SECRETASE INHIBITOR IV(797035-11-1)
• EPA Substance Registry System: BETA-SECRETASE INHIBITOR IV(797035-11-1)

Safety Data

• Hazardous Substances Data: 797035-11-1(Hazardous Substances Data)

Usage

Uses

beta-Secretase Inhibitor IV is a compound that binds to the active site of BACE-1 and potently blocks its proteolytic activity.

Upstream product

• 695215-95-3 methyl-3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate 
• 695215-93-1 dimethyl-5-[methyl(methylsulfonyl)amino]isophthalate 
• 695215-94-2 3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 695215-92-0 3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid 
• 695215-98-6 (1S,2R)-(1-benzyl-3-cyclopropylamino-2-hydroxypropyl)carbamic acid tert-butyl ester 
• 62814-45-3 5-methanesulphonylamino-isophthalic acid dimethyl ester 

Relevant articles and documents

Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1)

We describe the development of cell-permeable β-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell