797058-05-0Relevant academic research and scientific papers
Synthesis of tailor-made glycoconjugate mimetics of heparan sulfate that bind IFN-γ in the nanomolar range
Lubineau, Andre,Lortat-Jacob, Hugues,Gavard, Ollivier,Sarrazin, Stephane,Bonnaffe, David
, p. 4265 - 4282 (2004)
We have recently described the preparation of three building blocks for the combinatorial synthesis of heparan sulfate (HS) fragments. Herein we show that one of these building blocks (disaccharide 4) allows the preparation, in high yields and with total
Compounds that bind to the interferon-gamma, preparation method thereof and medicaments containing same
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Page/Page column 22, (2008/06/13)
Compound capable of binding to gamma-interferon (γ-IFN), chosen from the molecules corresponding to formula (I) below: in which X is a divalent spacer group that is sufficiently long to allow the two oligosaccharide fragments A and B to each bind to one of the peptide sequences 125 to 143 of the C-terminal ends of a γ-interferon (γ-IFN) homodimer, n represents an integer from 0 to 10, and for example equal to 0, 1, 2, 3, 4 or 5, and each R independently represents a hydrogen atom, an SO3? group or a phosphate group, on the condition that no SO3? group is in the 3-position of the glucosamine units of compound (I). The invention also relates to the process for preparing these compounds, to the complexes formed by these compounds and gamma-interferon, and to the medicaments comprising these compounds or complexes.
