79714-16-2Relevant academic research and scientific papers
I2/CHP-Mediated Oxidative Coupling of 2-Aminobenzamides and Isocyanides: Access to 2-Aminoquinazolinones
Wei, Tian-Qi,Xu, Pei,Wang, Shun-Yi,Ji, Shun-Jun
, p. 5393 - 5398 (2016/11/22)
An oxidative coupling of 2-aminobenzamides 1 and isocyanides 2 mediated by I2and cumyl hydroperoxide (CHP) leads to the formation of 2-aminoquinazolinones 3 in moderate to excellent yields. This method provides an efficient approach to 2-aminoq
Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion
Vlaar, Tj?stil,Cioc, Razvan C.,Mampuys, Pieter,Maes, Bert U. W.,Orru, Romano V. A.,Ruijter, Eelco
supporting information, p. 13058 - 13061 (2013/02/26)
Heterocycles containing a guanidine moiety are of great importance in medicinal chemistry (Scheme 1).[1] As a result, several methods for the synthesis of these "privileged scaffolds" have been reported.[2, 3] Classical approaches, such as the addition of diamines to isothiocyanates followed by condensation and the coupling of diamines with cyanogen bromide,[2, 4] have some clear limitations, such as the availability and toxicity of reagents. Moreover, these procedures suffer from poor atom and/or step efficiency, thus making them unattractive from a sustainability point of view.
A NOVEL SYNTHESIS OF 2-SUBSTITUTED QUINAZOLIN-4(3H)-ONES
Svetlik, Jan
, p. 1281 - 1285 (2007/10/02)
Aromatic or mixed carbodiimides and ketenimines react with ethyl allophanate to give corresponding substituted quinazolin-4(3H)-ones.
