79722-73-9Relevant academic research and scientific papers
Metallo Aldimines. 3. Coupling of Lithium Aldimines with Aryl, Vinyl, and Acetylenic Halides
Marks, Maurice J.,Walborsky, Harry M.
, p. 52 - 56 (2007/10/02)
tert-Butyllithium aldimine, an acyl anion equivalent derived from 1,1,3,3-tetramethylbutyl isocyanide (TMBI) and tert-butyllithium, couples with aryl, vinyl, and acetylenic halides to give the corresponding ketimine which upon hydrolysis affords the corresponding ketones.These coupling reactions appear to result from halogen-metal exchange followed by addition-elimination to give the observed products.
