79740-05-9

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 74-88-4 methyl iodide 

Downstream Products

• 151655-69-5 desmosdumotin B 
• 426823-13-4 2-[(1'-hydroxy-2'-ene-3'-phenyl) propenylene]-5-methoxy-4,6,6-trimethyl-1,3-cyclohexene(4,5)-diketone 
• 13197-12-1 3-Brom-3,5,5-trimethyl-1-acetyl-cyclohex-1-en-2-ol-4,6-dion 

Relevant academic research and scientific papers

Frutescone A-G, Tasmanone-Based Meroterpenoids from the aerial parts of Baeckea frutescens

Frutescone A-G [(1-6), (+)-7, (-)-7], a new group of naturally occurring tasmanone-based meroterpenoids, were isolated from the aerial parts of Baeckea frutescens L. Compounds 1 and 4 featured a rare carbon skeleton with an unprecedented oxa-spiro[5.8] tetradecadiene ring system, existing as two favored equilibrating conformers in CDCl3 solution, identified by variable-temperature NMR. The regioselective syntheses of 4-7 were achieved in a concise manner by a biomimetically inspired key hetero-Diels-Alder reaction "on water". Compounds 1, 4, and 5 exhibited moderate cytotoxicities in vitro.

Novel cyclopeptide and unique flavone from Desmos rostrata. Total synthesis of desmorostratone

Two new compounds, a cyclic peptide desmocyclopeptide (1) and a special flavone desmorostratone (2) were isolated from the stem bark of Desmos rostrata, along with two known compounds, desmosdumotins B (3) and C (4). Their structures were established on the basis of the spectral data, including mass spectrometry and 2D NMR. The total synthesis of desmorostratone (2) was performed in order to confirm its structure as well as that of desmosdumotin C (4), which was a tautomeric mixture in the solution. Finally, cytotoxity of these compounds were evaluated. Desmosdumotin C (4) displayed a moderate inhibition activity against KB cell line with an IC50 of 19.2 μM, whereas the other products showed a weak inhibition against the same cell line target.

Desmosdumotins, the Method for Preparing the Same and Use as Anti-Tumor or Anti-AIDS Agents

This invention discloses the method for preparing desmosdumotin C, the series of desmosdumotin C derivatives and their manufactures, and the total synthesis of desmosdumotin B. The invention also discloses uses of the derivatives and pharmaceutical compos

First total synthesis of desmosdumotin C

Desmosdumotin C (1), a novel compound isolated from the roots of Desmos dumosus, was synthesized from 2,4,6-trihydroxyacetophenone (2), confirming the assigned structure of the natural product. Copyright Taylor & Francis, Inc.