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ETUDE D'UN SCHEMA DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE A L'AIDE DE DERIVES DU PHOSPHORE TETRAEDRIQUE
Mulliez, M.
, p. 2027 - 2041 (1981)
A new scheme of repetitive and controlled peptide synthesis offers two advantages compared to the usual methods of synthesis: two steps only are used for the prolongation of a peptide chain with an amino-acid residue and the risk of racemisation is minimized.The two postulated steps are verified particularly by the rearrangement, in an alkaline alcoholic medium, of phosphordiamides 1 incorporating one amino-acid residue, leading to the formation of the peptide derivatives 6 and 8.The severe limitations of this method are discussed.
