797762-79-9Relevant academic research and scientific papers
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators
Morera, Enrico,De Petrocellis, Luciano,Morera, Ludovica,Moriello, Aniello Schiano,Nalli, Marianna,Di Marzo, Vincenzo,Ortar, Giorgio
supporting information; experimental part, p. 1674 - 1677 (2012/04/04)
In order to explore the structural determinants for the TRPV1 and TRPA1 agonist properties of gingerols, aseries of nineteen analogues (1b-5) of racemic [6]-gingerol (1a) was synthesized and tested on TRPV1 and TRPA1 channels. The exploration of the structure-activity relationships, by modulating the three pharmacophoric regions of [6]-gingerol, led to the identification of some selective TRPV1 agonists/desensitizers of TRPV1 channels (3a, 3f, and 4) and of some full TRPA1 antagonists (2c, 2d, 3b, and 3d). 2011 Elsevier Ltd. All rights reserved.
Synthesis and evaluation of estrogen agonism of diaryl 4,5- dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: A compound set forming a 4D molecular library
Pulkkinen, Juha T.,Honkakoski, Paavo,Per?kyl?, Mikael,Berczi, Istvan,Laatikainen, Reino
supporting information; experimental part, p. 3562 - 3571 (2009/04/06)
In this paper, the preparation and systematic evaluation of estrogen receptor α (ERα) and estrogen receptor β (ERβ) activities of some diaryl-1,3-diones and their synthetic intermediates, diaryl-4,5-dihydroisoxazoles, diaryl-3-hydroxyketones, diaryl-3-met
Synthetic stitching with silicon: Geminal alkylation-hydroxylation of alkynyl carbonyl compounds
Trost, Barry M.,Ball, Zachary T.
, p. 13942 - 13944 (2007/10/03)
A new strategy for the synthesis of β-carbonyl-substituted tertiary alcohols from α,β-alkynyl ketones and esters has been demonstrated. A silicon tether is used to internally deliver an alkyl group, which, combined with a C-Si to C-O transformation, can r
