797763-33-8Relevant academic research and scientific papers
Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates
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Page/Page column 7, (2010/08/18)
The invention relates to novel and known substituted phosphonates for use in ameliorating amyloid aggregates, particularly for use in the treatment of Alzheimer's disease.
Unexpected non-stability of aminophosphonates: Limitation of their synthesis using diphenylmethylamine procedure
Zon,Miziak,Rychlewski,Gancarz
, p. 2023 - 2030 (2008/09/18)
New diethyl 1-diphenylmethylaminoalkylphosphonates from aldehydes, ketones, diphenylmethylamine and diethyl phosphite were obtained. Their stability in acidic media as determined by 31P NMR spectroscopy strongly depends on the basicity of the nitrogen atom. The bulky N-substituent can drastically decrease the stability of the ester during acidic hydrolysis leading to decomposition products in the retro Kabachnik-Fields like reaction.
