797804-53-6

Usage

Derivative of indazole

A heterocyclic aromatic organic compound

Potential applications

Pharmaceutical and medicinal chemistry

Use as building block

In the synthesis of various heterocyclic compounds and drug molecules

Stability

Enhanced by the 5-methyl ester group, suitable for use in various chemical reactions

Biological activities and pharmacological properties

Of interest for further research and development in drug discovery and medicinal chemistry.

Upstream product

• 797804-50-3 3-formyl-1H-indazole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Indazole-derivatives as factor Xa inhibitors

The present invention relates to compounds of the formulae I and Ib wherein R0 ; R1 ; R2 ;Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae I and Ib, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.