79782-60-8Relevant academic research and scientific papers
Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties
Olson, Gary L.,Cheung, Ho-Chuen,Chiang, Elliot,Madison, Vincent S.,Sepinwall, Jerry,et al.
, p. 2866 - 2879 (2007/10/02)
The design and synthesis of peptide mimetics of thyrotropin-releasing hormone (TRH) in which the peptide backbone is entirely replaced by a cyclohexane framework are described.The cis-1,3,5-trisubstituted ring was expected to permit key pharmacophoric gro
Aminobenzylation d'aldehydes phosphoniques: preparation d'acides aminoalkylphosphoniques
Fabre, Genevieve,Collignon, Noel,Savignac, Philippe
, p. 2864 - 2869 (2007/10/02)
The reaction of phosphonic aldehydes with benzylamine in presence of NaBH3CN yields benzylaminoalkylphosphonates which, submitted to catalytic hydrogenation, lead to phosphonic amino esters.When reductive amination is carried out with H2/Pd reduction and debenzylation are observed simultaneously.In the absence of reducing agent the enaminobenzylphosphonate can be isolated and N-alkylated.Hydrolysis of phosphonic amino-esters with dilute HCl gives phosphonic amino acids.The order of occurence of each operation, as well as the choice of the catalyst is discussed.
