79782-64-2Relevant academic research and scientific papers
[(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositions and use
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, (2008/06/13)
[(5-oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula STR1 wherein R1 is hydrogen, lower alkyl or aryl-lower alkyl; R2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, STR2 wherein R5 and R6 are hydrogen, lower alkyl or aryl-lower alkyl; R3 and R4, independently, are hydrogen, lower alkyl, or aryl-lower alkyl; and enantiomers, diastereomers, and racemates thereof, and, when R2 is STR3 pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age-associated memory impairment.
Aminobenzylation d'aldehydes phosphoniques: preparation d'acides aminoalkylphosphoniques
Fabre, Genevieve,Collignon, Noel,Savignac, Philippe
, p. 2864 - 2869 (2007/10/02)
The reaction of phosphonic aldehydes with benzylamine in presence of NaBH3CN yields benzylaminoalkylphosphonates which, submitted to catalytic hydrogenation, lead to phosphonic amino esters.When reductive amination is carried out with H2/Pd reduction and debenzylation are observed simultaneously.In the absence of reducing agent the enaminobenzylphosphonate can be isolated and N-alkylated.Hydrolysis of phosphonic amino-esters with dilute HCl gives phosphonic amino acids.The order of occurence of each operation, as well as the choice of the catalyst is discussed.
