79802-78-1Relevant academic research and scientific papers
Carbon-13 magnetic resonance: hydrogen involvement in γ-anti substituent effects
Forrest, T. P.,Thiel, J.
, p. 2870 - 2875 (2007/10/02)
Chemical shifts have been determined for the carbons in a series of 3,3-dimethylcyclohexyl derivatives, (substituent = H, CH3, NH2, OH, Cl, Br, I).Comparison of the γ-anti substituent effects at carbons 3 and 5 indicates that presence of axial protons on these carbons causes increased shielding by all of the above substituents.The shielding by γ-anti substituents is decreased by the replacement of either the α or γ protons by methyl groups; the extent of the decrease is dependent upon the substituent and upon the position of the hydrogen which is replaced.
