79814-60-1

Basic information

• Product Name: (1S,2S,8S,8aR,3'R,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3',5'-dihydroxy-2-methyl-8-<(2-methyl-1-oxobutyl)oxy>-1-naphthaleneheptanoate
• Synonyms: (1S,2S,8S,8aR,3'R,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3',5'-dihydroxy-2-methyl-8-<(2-methyl-1-oxobutyl)oxy>-1-naphthaleneheptanoate
• CAS NO: 79814-60-1
• Molecular Weight: 422.562
• Mol File: 79814-60-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1S,2S,8S,8aR,3'R,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3',5'-dihydroxy-2-methyl-8-<(2-methyl-1-oxobutyl)oxy>-1-naphthaleneheptanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,8S,8aR,3'R,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3',5'-dihydroxy-2-methyl-8-<(2-methyl-1-oxobutyl)oxy>-1-naphthaleneheptanoate(79814-60-1)
• EPA Substance Registry System: (1S,2S,8S,8aR,3'R,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3',5'-dihydroxy-2-methyl-8-<(2-methyl-1-oxobutyl)oxy>-1-naphthaleneheptanoate(79814-60-1)

Safety Data

• Hazardous Substances Data: 79814-60-1(Hazardous Substances Data)

Upstream product

• 79782-56-2 5-Hydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-(2-methyl-butyryloxy)-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]-3-oxo-heptanoic acid methyl ester 
• 85737-93-5 2-Methyl-butyric acid (1R,4S,4aR,7R,8R,8aS)-4-acetoxy-8-allyl-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 
• 85737-91-3 Acetic acid (3aS,4S,6aS,7R,9aS,9bR)-2-bromomethyl-4-methyl-2,3,3a,4,6a,7,8,9,9a,9b-decahydro-benzo[de]chromen-7-yl ester 
• 85737-88-8 Acetic acid (1R,4S,4aR,5R,8aS)-5-allyl-4-methoxy-6-methyl-8-oxo-1,2,3,4,4a,5,8,8a-octahydro-naphthalen-1-yl ester 
• 85737-90-2 Acetic acid (1R,4S,4aR,5S,6S,8aS)-5-allyl-4-methoxy-6-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester 
• 85737-92-4 Acetic acid (1R,4S,4aR,5S,6S,8aS)-5-allyl-4-hydroxy-6-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl ester 
• 85737-85-5 (4aR,5S,8R,8aS)-5-Hydroxy-8-methoxy-4a,5,6,7,8,8a-hexahydro-1H-naphthalen-2-one 
• 79782-47-1 (4aα,8aβ)-5β,8α-bis(benzyloxy)-2β-methyl-3-oxo-1β-<3-(1-ethoxyethoxy)propyl>decahydronaphthalene tosylhydrazone 
• 79782-44-8 Methanesulfonic acid (1R,4aR,5S,8S,8aR)-5,8-bis-benzyloxy-1-[3-(1-ethoxy-ethoxy)-propyl]-3-oxo-decahydro-naphthalen-2-ylmethyl ester 
• 79782-43-7 (4aα,8aβ)-5β,8α-bis(benzyloxy)-2(hydroxymethyl)-3-oxo-1β-<3-(1-ethoxyethoxy)propyl>decahydronaphthalene 
• 79782-45-9 (4aα,8aβ)-5β,8α-bis(benzyloxy)-2-methylene-3-oxo-1β-<3-(1-ethoxyethoxy)propyl>decahydronaphthalene 
• 79782-42-6 (3R,4R,4aR,5S,8S,8aR)-5,8-Bis-benzyloxy-4-[3-(1-ethoxy-ethoxy)-propyl]-3-methyl-octahydro-naphthalen-2-one 
• 79782-48-2 5β,8α-dibenzyloxy-2β-methyl-1β-<3-(1-ethoxyethoxy)propyl>-1,2,4aα,5,6,7,8,8aβ-octahydronaphthalene 
• 79782-37-9 7α-acetoxy-1β,4α-bis(benzyloxy)-6β-(phenylselenyl)-4aβ,8aα-decahydronaphthalene 

Downstream Products

• 73573-88-3 mevastatin 
• 84173-31-9 3,5-bis-epi-compactin 
• 84173-30-8 3-epi-compactin 
• 84173-29-5 5-epi-compactin 
• 73573-88-3 (+/-) compactin 

Relevant articles and documents

Total synthesis of (+)-compactin by a double Michael protocol

The total synthesis of (+)-compactin 1 has been achieved by employing a double Michael reaction of (R)-1-acetyl-3-(tert-butyldimethylsiloxy)cyclohexene 16 with methyl crotonate as the key reaction.

Total synthesis of the hypocholesterolemic agent compactin

A total synthesis of ( plus )-compactin (ML-236B), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, is presented. The key chiral hexahydronaphthalene intermediate was efficiently synthesized in 70% overall yield from the optically active diol. In turn, the diol was obtained via microbiological reduction of the racemic dione. ( plus )-Compactin was prepared in 14 steps from the chiral hexahydronaphthalene intermediate in 0. 8% yield. Refs.

The total synthesis of (±) compactin and its natural (+) enantiomer

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