79816-14-1

Basic information

• Product Name: 3',5'-di-O-benzoyl-2'-O-methyluridine
• Synonyms: 3',5'-di-O-benzoyl-2'-O-methyluridine
• CAS NO: 79816-14-1
• Molecular Weight: 466.447
• Mol File: 79816-14-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3',5'-di-O-benzoyl-2'-O-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-di-O-benzoyl-2'-O-methyluridine(79816-14-1)
• EPA Substance Registry System: 3',5'-di-O-benzoyl-2'-O-methyluridine(79816-14-1)

Safety Data

• Hazardous Substances Data: 79816-14-1(Hazardous Substances Data)

Upstream product

• 68045-07-8 1,3,5-tri-O-benzoyl-2-O-methyl-α-D-ribofuranose 
• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 

Downstream Products

• 2140-76-3 2'-O-methyluridine 
• 2140-76-3 2'-O-methyluridine 

Relevant articles and documents

Apparatus and processes for the large scale generation and transfer of diazomethane

For large scale preparation of pyrimidine ribonucleosides, the intermediate 2-O-methyl-(or ethyl)-1,3,5-tri-O-benzoyl-α-D-ribose can be prepared using a diazomethane (or diazoethane) reaction that is controlled via an inert solvent transferring system. This transfer system allows for large scale preparations of the pyrimidine ribonucleosides.

Synthesis of 2',3'-Differentiated Ribonucleosides via Glycosylation. Reactions with 2-O-Me or 2-O-TBDMS Ribofuranose Derivatives. 1. Pyrimidine Series

The synthesis of 2',3' asymmetrically substituted pyrimidine ribonucleosides in 70-95percent yields by using modified Vorbruggen conditions with "nonparticipating" 2-O-CH3 and 2-O-TBDMS ribofuranoses is described.Such compounds are useful synthons for oligoribonucleotide synthesis, including incorporation of "rare" bases.New and practically useful conditions for placement (using 1,2,4-triazole) and removal (KF/crown ether) of the tert-butyldimethylsilyl (TBDMS) protecting group are also reported.